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108,109 For example, in a single-site vehicle-controlled double-blinded study examining 79 female subjects aged 5380 years that applied the MEP treatment twice per day for 14 weeks displayed significant improvement in facial skin dryness, laxity, and dullness (Figure 6)

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462 Compared with placebo, long-term administration (e.g., 25 mg or 100 mg every 8 h for 12 weeks) significantly decreased mPAP and improved the 6 min walk distance, with good tolerability

Vargas-Soria M, Ramos-Rodriguez JJ, Del Marco A, Hierro-Bujalance C, Carranza-Naval MJ, Calvo-Rodriguez M, et al